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Lesch-Nyhan syndrome

Lesch-Nyhan syndrome, hereditary metabolic disorder, affecting the central nervous system. First described in 1964 by William Nyhan and Michael Lesch, it is caused by a defective enzyme hypoxanthine-quinine-phos-phoribasyl-transferase, which is normally very active in brain cells. It is characterized by mental retardation, aggressive behavior and a tendency to inflict self injury. The syndrome is transmitted by a recessive sex-linked gene and primarily affects males. There is no cure or effective treatment.

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21st Century Webster's Family Encyclopedia21st Century Webster's Family Encyclopedia - Lange, Dorothea to Lilac